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Fast and Accurate Monomodal 3D High Resolution Deep Registration of Drosophila Larval Brain Volumes

arXiv · AI, language, vision and robotics · article · Sep 10, 2026 · UTC

The larval stage of Drosophila melanogaster is a compact model system for neuroscience whose genetic toolkit allows fluorescent markers to be expressed in defined neural populations, and comparing the resulting expression patterns across animals requires every brain to be registered into a shared anatomical reference space. Existing pipelines for this task are predominantly based on classical registration methods, which perform a new optimization for each volume, often require per-case parameter tuning, and can take minutes per brain, limiting their use as a routine preprocessing step. We pres

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