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USING ARTIFICIAL INTELLIGENCE TO BRIDGE HUMAN AND MURINE STUDIES OF LUPUS NEPHRITIS PROGRESSION - PROJECT SUMMARY LUPUS NEPHRITIS (LN) IS THE MOST COMMON SEVERE MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) DISEASE

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USING ARTIFICIAL INTELLIGENCE TO BRIDGE HUMAN AND MURINE STUDIES OF LUPUS NEPHRITIS PROGRESSION - PROJECT SUMMARY LUPUS NEPHRITIS (LN) IS THE MOST COMMON SEVERE MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) DISEASE PROGRESSION IS ASSOCIATED WITH TUBULOINTERSTITIAL HYPOXIA AND METABOLIC DYSFUNCTION, CAPILLARY RAREFACTION, ACCUMULATION OF IMMUNE INFILTRATES AND FIBROSIS. COMPLETE REMISSION RATES IN PATIENTS WITH LN ARE <50% (AND OFTEN <30%) EVEN IN THE SETTING OF RIGOROUS CLINICAL TRIALS AND RESPONSES CANNOT CURRENTLY BE PREDICTED BY CLINICAL AND HISTOLOGIC FEATURES AT INITIAL BIOPSY. WE C

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