SOURCE-LINKED INTELLIGENCE

Tuberculosis Antimicrobial Stewardship Program (TASP): tackling Bedaquiline-resistant tuberculosis

CORDIS · observation · Publication date unknown

rapidly reduce bacillary load in patients at risk/with BDQr/Rr-TB by using an empirical highly bactericidal intensive phase (for those at risk) followed by drug-susceptibility testing (DST)-informed artificial intelligence (AI)-aided Treatment Recommender's regimen composition. 125 participants at risk/with BDQr/Rr-TB will be enrolled in Nigeria, Mozambique and South Africa. Baseline and acquired resistance will be monitored and a novel, fast and quantitative phenotypic method (thin layer agar), with little infrastructural requirements, will be evaluated in TASP’s high burden, limited resource settings through decentralized implementation. Additionally, TASP will improve environmental control with co-designed, portable air cleaners, built sourcing low-cost materials from the local market. Filter waste products will be used for resistance surveillance and compared to conventional bio-aerosol samplers. The anticipated impact of TASP is a cost-effective TB antimicrobial stewardship programme that reduces further resistance development and salvages the current all-oral BDQ regimens

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recordType

award

status

SIGNED

region

EU

value

5999990.75

unit

EUR