SOURCE-LINKED INTELLIGENCE

Exploiting Nanopore sequencing to discover what microbes eat

CORDIS · observation · Publication date unknown

viruses or to regulate activity. In NanoEat we will exploit this feature using the raw Nanopore sequencing signal that, in principle, enables discovery of any type of modified DNA. By developing new machine learning frameworks that can identify these species-specific modification patterns we can utilize this novel feature to supercharge recovery of individual microbial genomes from complex communities. Furthermore, by supplying synthetic nucleotides, that can be detected by Nanopore sequencing, we hypothesize that it is possible to estimate how microbes grow, by using the incorporation rate of these synthetic nucleotides to estimate replication in complex communities at scale.

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recordType

award

status

SIGNED

region

EU

value

1455274

unit

EUR