SOURCE-LINKED INTELLIGENCE
Cellular crosstalk driving Tertiary Lymphoid Structure formation across tissues
wnstream effects of ligands and receptors will be unraveled with multiome (RNA+open chromatin) sequencing using human tonsil organoids. The observed effects will be generalised to other tissues using machine learning and deep learning models, resulting in a tissue-specific reference of signalling and regulatory genes controlling TLS biogenesis. Overall, this project aspires to provide a detailed look into TLS biology, while defining the bases for their therapy-oriented manipulation. Tertiary Lymphoid Structures, tissue specifity, scRNA-seq, cell-cell communication, autoimmunity
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- recordType
- award
- status
- SIGNED
- region
- EU
- value
- 156778.56
- unit
- EUR
Evidence & attribution
European Commission, CORDIS Horizon Europe project dataset. Metadata adapted.
License: CORDIS reuse policy
First collected: 2026-09-20T02:21:08.944Z. This is not the publication date.