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Precision Lethality to overcome clonal heterogeneity in high-risk neuroblastoma

CORDIS · observation · Publication date unknown

e before drug perturbation of cells that are known to be either drug resistant or drug sensitive. Combined with publicly available drug sensitivity data repositories, this will be used to construct a deep learning model to predict drug sensitivities of individual cells. Successful completion of this multi-disciplinary research program will identify and verify new drugs to complement standard of care consolidation therapy for neuroblastoma. I also envision that these studies will showcase to the broader cancer research community how cell barcoding can be used as a drug combination strategy to overcome clonal heterogeneity, which would increase the chances of finding curative cancer treatments. Drug response, Drug synergy, Drug response prediction, Deep learning, Single cell sequencing, Cell barcoding, Expressed Cellular Barcodes, Precision Lethality, Microwells, Lineage tracing, Rare cell survival

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recordType

award

status

SIGNED

region

EU

value

1497981

unit

EUR