SOURCE-LINKED INTELLIGENCE

ProMeta: Few-shot PROTAC-targeted degradation prediction across E3 ligases

arXiv · AI, language, vision and robotics · article · Sep 9, 2026 · UTC

Proteolysis-targeting chimeras (PROTACs) have emerged as a transformative therapeutic strategy that selectively degrades historically ''undruggable'' targets via the ubiquitin-proteasome system. Despite growing efforts to develop computational predictors of PROTAC degradation activity, existing supervised approaches remain severely challenged by data scarcity and imbalance across E3 ligases, limiting their ability to generalize beyond well-studied ligase contexts. In practice, labeled data are heavily concentrated on a few ligases (e.g., CRBN and VHL), while the majority of E3 ligases remain u

Read original source ↗ Open in workspace

recordType

paper

region

Global