SOURCE-LINKED INTELLIGENCE

Smart Platforms for Osteochondral Regeneration through on-demand Activation

CORDIS · observation · Publication date unknown

ntiation, and guidance of extracellular matrix deposition directly in situ. The project will progress through four main steps: (i) defining biomaterials, requirements, and regulatory frameworks using Artificial Intelligence (AI) tools; (ii) developing stimuli-responsive biomaterials and biofabricating the OC unit; (iii) optimizing external stimulation to modulate GF release; and (iv) validating the OC unit in vitro to assess human stem cell differentiation and tissue-specific matrix production. Clinically, SPORA aims to restore OC lesions and delay or prevent OA progression, but, beyond this impactful goal, the paradigm developed in SPORA can be readily adapted to other tissues and diseases (e.g., cardiac, wound, and muscle repair) by modulating the specific bioactive factors and optimizing their stimulus-driven delivery, thus opening the path toward a new era of adaptive regenerative biomaterials. Stimuli-responsive biomaterials, Biofabrication, Biophysical external stimuli, Electric and Magnetic fields, Regenerative Medicine, Osteochondral tissue, Artificial Intelligence, Osteoarth

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recordType

award

status

SIGNED

region

EU

value

191343.12

unit

EUR