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AI-DESIGNED MINI-PROTEINS AS DRIVERS OF PANCREATIC ISLET PRODUCTION FROM PLURIPOTENT STEM CELLS - THE ABILITY TO DIFFERENTIATE STEM CELLS (SC) INTO FUNCTIONAL PANCREATIC ISLETS HIGHLIGHTS NEW OPPORTUNITIES TO ADDRESS THE

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AI-DESIGNED MINI-PROTEINS AS DRIVERS OF PANCREATIC ISLET PRODUCTION FROM PLURIPOTENT STEM CELLS - THE ABILITY TO DIFFERENTIATE STEM CELLS (SC) INTO FUNCTIONAL PANCREATIC ISLETS HIGHLIGHTS NEW OPPORTUNITIES TO ADDRESS THE TISSUE SHORTAGE FOR CELL REPLACEMENT THERAPIES IN DIABETES. HOWEVER, A BARRIER TO THE BROAD APPLICABILITY OF THIS APPROACH ACROSS THE HUMAN POPULATION IS THE VARIABLE EFFICIENCY OF CURRENT PROTOCOLS IN CONTROLLING LINEAGE BIASES AND FUNCTIONAL MATURATION OF DIFFERENT SC LINES, THEREBY YIELDING HETEROGENEOUS ISLET CELL PREPARATIONS CONTAINING VARIABLE PROPORTIONS OF ENDOCRINE A

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award

region

US

value

3424540

unit

USD