SOURCE-LINKED INTELLIGENCE
Targeted Re-engineering of the Tumor Matrix to Advance Immunotherapy
xamined in advanced 3D in vitro and in vivo pancreatic tumor models. The combined effects of biomimetics on the matrisome, matrix architecture and single-cell transcriptomics will be integrated using machine learning to identify ECM fingerprints. OpenMatrix will 1) deliver mechanistic insights into endogenous fibrosis drivers and antagonists, 2) engage these cell-intrinsic mechanisms to revert fibrosis and, thereby, 3) reactivate immune effector function and advance immunotherapy. Tumor stroma, cancer-associated fibroblasts, nanomedicine, drug delivery, extracellular matrix
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- recordType
- award
- status
- SIGNED
- region
- EU
- value
- 2499783.75
- unit
- EUR
Evidence & attribution
European Commission, CORDIS Horizon Europe project dataset. Metadata adapted.
License: CORDIS reuse policy
First collected: 2026-09-20T03:21:21.440Z. This is not the publication date.