SOURCE-LINKED INTELLIGENCE

SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign

Apple Machine Learning Research · article · Sep 11, 2026 · UTC

Proteins are fundamental to biological processes, with their function determined by the complex interplay between the amino acid sequence and the three-dimensional structure. Developing generative models capable of understanding this intrinsically multi-modal relationship is crucial for fields like drug discovery and protein engineering. Existing models often rely on a multi-stage training process where autoencoders that tokenize data into latent representations are trained in a first stage. Secondly, a generative model is trained on the latent representation of the autoencoder(s), i.e…

Read original source ↗ Open in workspace

recordType

article

region

Global