SOURCE-LINKED INTELLIGENCE
Engineering new enzymatic platforms for atroposelective C–N bond formation
cess electron-rich biaryl atropisomers with atroposelective SNAr reactions to generate electron-poor counterparts. Directed evolution will be applied to enhance activity and selectivity, supported by machine learning to accelerate optimisation and computational protein design to improve enzyme function. Together, these studies will establish a biocatalytic platform for the efficient, sustainable synthesis of drug-like atropisomeric compounds. Biocatalysis, atropisomers, enzyme engineering, atroposelective, protein design, enzyme design, directed evolution, nitrene transfer, chemoenzymatic synthesis.
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- recordType
- award
- status
- SIGNED
- region
- EU
- value
- 355301.04
- unit
- EUR
Evidence & attribution
European Commission, CORDIS Horizon Europe project dataset. Metadata adapted.
License: CORDIS reuse policy
First collected: 2026-09-20T05:31:32.981Z. This is not the publication date.