SOURCE-LINKED INTELLIGENCE

Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes: Unraveling the Molecular Complexities

CORDIS · observation · Publication date unknown

ice, we will selectively deplete key amidated hormones that counteract the effects of GLP-1RAs and dissect their contribution in physiological readouts of GLP-1RA resistance. Lastly, we will leverage machine learning approaches to clinical data analysis on large deeply phenotyped biomedical cohorts to select for patient characteristics that determine the likelihood of developing GLP-1RA resistance, and to assess the combinatorial contribution of amidated hormones on T2DM susceptibility. By combining experimental and computational approaches, this project aims to gain a deeper understanding of the complex interplay between endogenous hormones (and their combinatorial effects) and GLP-1 signaling, to develop more effective and personalized therapies, and ultimately to improve clinical outcomes in individuals with T2DM. GLP-1 receptor agonists, Type 2 Diabetes Mellitus, amidated hormones, GLP1-RA

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recordType

award

status

SIGNED

region

EU

value

1500000

unit

EUR