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Dissecting chromosomal instability in gastric cancer and its role in immunoediting using advanced functional and multiplexed single cell sequencing technologies

CORDIS · observation · Publication date unknown

croenvironment, and elucidating the molecular pathways leading to the poor prognosis of CIN-gastric cancer. To fulfill this aim, I defined three research objectives: In Objective I, I will develop a deep learning-based functional single cell sequencing (deepFUNseq) method to identify and profile rare, naturally occurring CIN-mother and -daughter cells derived from CIN-gastric cancer patients. In Objective II, I will develop a multiplexed functional & spatial single cell sequencing method(multi-FUNseq) to transcriptomically profile (non-)CIN gastric cancer cells and their interacting immune cells. In Objective III, I will investigate CIN-driving mechanisms and CIN-associated consequences in CIN-gastric cancer, including the role of CIN in immunoediting. The technologies developed in this proposal will result in a leap in our understanding of CIN in the context of cancer, and will lead to advances in fields where profiling cell-cell interactions is important, like tumor immunology. Single cell technology, Single cell sequencing, Multi-omics profiling, Spatial transcriptomics, Mult

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recordType

award

status

SIGNED

region

EU

value

2000000

unit

EUR