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Weakly Supervised Spatial Grounding for Discriminative Attention-Based Ultrasound-Histopathology Alignment in Prostate Cancer Grading

arXiv · AI, language, vision and robotics · article · Sep 14, 2026 · UTC

Unpaired cross-modal distillation transfers grade structure from histopathology into a micro-ultrasound (micro-US) encoder by aligning a pooled needle-region embedding to a frozen histopathology teacher under grade-group correspondence alone. A single objective is thereby required to serve two distinct functions: rendering patch features discriminative of tissue state, and selecting which patches enter the pooled representation. We decouple them. Weak spatial supervision derived from percentage involvement, recorded routinely at biopsy, constrains the predicted proportion of malignant tissue w

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