SOURCE-LINKED INTELLIGENCE

Universal GPCR Activity Sensor for Next Generation Drug Discovery

CORDIS · observation · Publication date unknown

confidence compared to today's approaches. Its unique design supports streamlined drug discovery from the test tube to the native disease-relevant cell, as well as the capacity to efficiently harness artificial intelligence (AI) in the design of better drugs. The technology is based upon highly informative fluorescent sensor reagents that react to different receptor conformations with subtle, flexible changes in their structure. In this Pathfinder project, our main objective is to demonstrate that the conformational fingerprints generated by these sensors correlate to specific cellular signalling profiles, i.e. GPCR activity states (proof of principle). We believe that the UniSens platform will become the standard tool for early drug development and could be a game-changer in the search for safer, more effective drugs. GPCR, biased agonism, biosensor, machine learning

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recordType

award

status

SIGNED

region

EU

value

2965384.75

unit

EUR