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Bugs4Urate - Precision Nutrition Strategies for Investigating Probiotic, Diet, Glycan, and Microbiome Factors in Hyperuricemia and Gout Prevention

CORDIS · observation · Publication date unknown

extualizing factors of the habitual diet, host gut microbiome, and host genetics is used to establish a responder / non-responder instrument. We will employ a diverse array of methods, encompassing machine learning applied to existing clinical and omics observational data, ex-vivo dietary fiber and probiotic refinement, and two human intervention studies. In healthy adults (n = 8) we will conduct a mode-of-action study utilizing a crossover design including small intestine biopsy sampling to assess local activity. In hyperuricemic participants (n = 99) we will conduct a three-armed, placebo-controlled proof-of-concept study to access the efficacy of probiotic treatment (with and without fibre), combined with a responder / non-responder instrument. Using comprehensive longitudinal analyses in metabolomics, microbiome, transcriptomics, and glycomics, we aim to uncover the molecular dynamics between dietary patterns, established bacterial enzymatic processes, urate breakdown, and the resultant shifts in inflammation within the gut and throughout the circulatory system. By innovatin

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recordType

award

status

SIGNED

region

EU

value

4323350.75

unit

EUR