SOURCE-LINKED INTELLIGENCE

Decipher cytochrome P450 enzymes (CYPs) by digital tools to produce flavonoids and terpenoids

CORDIS · observation · Publication date unknown

f some molecules, the microbial production of oxygenated plant metabolites (OPMs) mediated by cytochrome P450 enzymes (CYPs) is still lagging, making them almost inaccessible to society. In contrast, artificial intelligence (AI) & machine learning (ML) tools are evolving rapidly, but their use for engineering biology is still underexplored. deCYPher applies these groundbreaking AI/ML techniques to unlock the OPM molecules to society. deCYPher develops a standardised AI/ML pipeline to implement AI/ML in each step of the Design-Build-Test-Learn cycle, and across all steps in the biotech value chain. Combined with smart databases & synthetic biology (SynBio) tools, this AI/ML pipeline will generate opportunities for the whole biotech sector. Specifically, applied to OPMs, we (1) bioprospect & select specific CYPs, (2) correctly localise & express CYPs and (3) optimise the microbial cells & bioprocess. deCYPher involves stakeholders (industry, regulators, NGOs) and engages European citizens across several countries. This allows to reflect on the societal ramifications of the convergence

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recordType

award

status

SIGNED

region

EU

value

6310073.75

unit

EUR