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Computation driven development of novel vivo-like-DNA-nanotransducers for biomolecules structure identification

CORDIS · observation · Publication date unknown

of molecular dynamics in one functional unit (ii), Use bioinformatics approaches to predict 3D structure of conformational states modelling real time evolution of interacting DNA-NT and proteins, and machine learning (ML) models to directly link the atomistic structure, conformational state, and dynamics (iii) Assess protein-DNA-NT binding by experimental approaches using linear and “on-chip” non-linear spectroscopies for the detection of vibrational signatures of organic molecular systems, to recognize consequent structural changes in the optical signal in real-time, (iv) Describe DNA-NT/protein interactions at the cellular level and 3D analysis of DNA-NT and model proteins, towards drug discovery. These research efforts will provide a foundation for a next generation of DNA-nanotransducers to be used for high-throughput functional molecular structure. Supercoiled DNA; DNA molecular modelling; conformational ensembles; enhanced-optical analysis; on-chip-photonics

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recordType

award

status

SIGNED

region

EU

value

3000418

unit

EUR