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DTI-Guided Volumetric Spherical Harmonics Regression for Single-to-Multi-Shell dMRI Synthesis

arXiv · AI, language, vision and robotics · article · Sep 13, 2026 · UTC

Multi-shell diffusion MRI (dMRI) unlocks more expressive microstructural modeling than single-shell scans, yet its longer acquisition time hinders deployment in large-scale cohorts and time-constrained clinical settings. Synthesizing an unobserved shell from a single-shell input is fundamentally ill-posed and further complicated by protocol mismatch, where source and target gradient direction sets may not align. We propose DTI-SHNet, a single-to-multi-shell synthesis framework that operates in the real symmetric spherical harmonics (SH) coefficient domain and performs spatially aware volumetri

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