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Deuterium labeling of GLUCOse improves magnetic resonance imaging Sensitivity to CANcer metabolism

CORDIS · observation · Publication date unknown

all metabolic products, which can be tracked by DMI. Building on our recent preliminary results in Nature Biomed, we propose a combination of novel MRI hardware, dynamic spectroscopic data sampling, deep learning algorithms, and a clinical validation to answer the following three research questions in a 5-year project: (i) Is DMI a viable alternative for whole-body cancer assessment? (ii) How is DMI positioned compared to Glc-sensitive PET? (iii) Can DMI be performed on widely available MRI systems and simultaneous with standard MRI? GLUCO-SCAN will fill a gap in current medical imaging by offering an alternative for whole-body PET examinations and potentially even for screening of high risk populations. Ultimately, it will pave the way for a new generation of MR scanners with all-in-one whole-body imaging capability that would capture morphologic and molecular information simultaneously. Magnetic resonance imaging, magnetic resonance spectroscopy, ultra-high field, glucose metabolism, oxidative/glycolytic metabolism, cancer diagnosis, oncology

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award

status

SIGNED

region

EU

value

2495924

unit

EUR