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Visualizing trans-splicing molecular machines across scales

CORDIS · observation · Publication date unknown

atory and abundant mRNA processing step. I will apply an ambitious approach that integrates in vitro and cell lysate-based methods, state-of-the-art cryo-EM, cryo-electron tomography, proteomics, and artificial intelligence-based computational modeling. I will complement the study through targeted functional experiments, leading to a complete understanding of the spatial-temporal resolution of trans-splicing in trypanosomes, with wider relevance to other organisms, including humans. The targeted fusion of gene sequences through trans-splicing bears potential as a molecular tool for transcriptome editing in the future. RNA processing, Trypanosoma brucei, splicing, cryo-EM, cryo-ET, biochemistry, protein-RNA complexes, molecular mechanism, structural biology

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recordType

award

status

SIGNED

region

EU

value

1999451

unit

EUR