SOURCE-LINKED INTELLIGENCE

New-to-nature biocatalysts with metal-substituted proteins

CORDIS · observation · Publication date unknown

ed enantio- and regioselectivity, even for substrates without directing groups. Our workflow integrates protein engineering, high-throughput screening, directed evolution, computational modelling and machine learning to obtain efficient, selective NoHaeCo biocatalysts. Target compounds include scaffolds related to Ensartinib, Sebetralstat and Etoricoxib. This interdisciplinary research combines i) biochemistry, ii) organometallic chemistry, iv) enzymology, and iv) computational science within the Thomas Ward group at the University of Basel, a world leader in artificial metalloenzymes. The fellowship will strengthen my scientific independence and competitiveness, equipping me with cutting-edge skills at the chemistry–biology interface. By advancing catalysis aligned with the European Green Deal, the project will reinforce Europe's leadership in sustainable synthesis for the pharmaceutical, agrochemical and fine-chemical sectors. Artificial metalloenzymes, directed evolution, biocatalysis

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recordType

award

status

SIGNED

region

EU

value

292118.88

unit

EUR