SOURCE-LINKED INTELLIGENCE

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

arXiv · AI, language, vision and robotics · article · Sep 10, 2026 · UTC

Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds. Despite the importance of this problem, existing benchmarks for adaptive hit discovery remain limited in scale and diversity. Here, we introduce AssayBench-Loop, a large-scale benchmark for adaptive hit discovery comprising 1,389 CRISPR screens across five phenotype categories. Beyond enabling systemat

Read original source ↗ Open in workspace

recordType

paper

region

Global