SOURCE-LINKED INTELLIGENCE

EPIGENETIC MEMORY BY COMMUNICATION ACROSS CHROMOSOME SCALES

CORDIS · observation · Publication date unknown

me replication across scales; we will develop new technology to address the interplay between 2D and 3D epigenome in epigenetic inheritance across replication. We will combine these technologies with machine learning, proteomics and fast-acting degrons to manipulate chromatin replication. Functionally, we will explore replication-induced 2D/3D dynamics and inheritance mechanisms in regulation of transcription and stem cell plasticity. Together, this will 1) provide the first knowledge of interdependencies and directionality in propagation of 2D and 3D organization, 2) reveal functions of DNA replication-induced plasticity in cell fate transitions, and 3) unveil spatio-temporal epigenetic mechanisms and their synergy with cis-based memory in maintaining cell identity. Chromatin replication, 3D genome organization, Cell fate decisions, Proteomics, Transcriptional regulation

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recordType

award

status

SIGNED

region

EU

value

2500000

unit

EUR