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Understanding Long-term Trends in Multi-pathogen Epidemiology in Africa using Multiplex Serological and Molecular Assays

CORDIS · observation · Publication date unknown

patients in longitudinal studies in Senegal, Cameroon, and Madagascar; (ii) Develop a multiplex serological assay for viral, parasitic, and bacterial pathogens in Africa; (iii) Create statistical and machine learning tools for multiplex data; and (iv) Implement sero-epidemiological analyses of long-term trends in infectious disease in general populations. The key technological output will be a multiplex serological assay using Luminex bead-based technology to measure antibodies to infectious diseases transmitted in Africa. The assay will test small volume blood samples for antibodies to >300 antigens from >100 pathogens. We will test samples from prospective cohorts of febrile patients to provide an in-depth assessment of the burden of febrile illness, and from 50,000 biobanked samples dating back over 30 years to assess long-term trends in multi-pathogen epidemiology in the general population. The knowledge generated from this interdisciplinary project will have major implications for how we study, track, prevent and treat febrile illness in Africa. Infectious disease epidemiology

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recordType

award

status

SIGNED

region

EU

value

2000000

unit

EUR